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17th November, 2017

Boyle et al. showed that CD4+ IL-10 producing Pf-specific T cells are of Th1 origin and are associated with reduced parasitemia in children from a high malaria endemic country.This suggests a role of IL-10+ …

29 October 2024

An interesting study thoroughly examines the role of Resident memory T cells in cancer immunology, focusing on their unique functions, mechanisms of action, and potential as therapeutic targets…

Malaria   Malaria is a vector borne disease, caused by an intracellular parasite, the protozoan Plasmodium spp. It affects most tropical areas of the world (Figure 1), where mosquitos of the Anopheles genus are present. Young children and pregnant women are especially vulnerable to malaria infection, and most of the mortality occurs among children under Read More

Cell-based Cancer Therapies Cytotoxicity is a property of some immune cells to induce lysis of other cells that can be detected as non-functional or transformed. In the recent years, redirecting cytotoxicity in cancer has been the base of cell-based cancer therapies that involve the use of living cells to treat cancer. There are several types Read More

Immunological systems function as soldiers to resist illness, but under some circumstances, the soldiers are reprogrammed to limit immunological response. These specific circumstances appear in cancer and illness.  These reprogrammed immune cells are one of the most exciting areas of study and targeting them can be extremely useful to patients.   These immunosuppressive cells are broadly Read More

Introduction Immunological tolerance describes a diverse range of host processes that prevent potentially harmful immune responses within that host (1). A fundamental property of the immune system is its ability to mediate self-defense with minimal collateral damage to the host. The system uses several different mechanisms to achieve this goal, which is collectively referred to Read More

15 January 2024

In a recent study, researchers uncovered a significant role played by beneficial commensal microbes in the gut: they stimulate the host to produce T cells that contribute to gut health by mitigating inflammation…

Colon carcinogenesis Carcinogenesis refers to the process by which normal cells transform into cancerous cells, and it involves genetic and epigenetic alterations that disrupt normal cellular functions, leading to uncontrolled cell growth and division. Colon carcinogenesis is a stepwise process initiated by genetic and epigenetic alterations, leading to the activation of oncogenes (e.g., KRAS) and Read More

HIV, the Microbiome and Cellular Immunity   HIV in infants Of the 2.1 million children under the age of 15 that live with HIV infection, 90% of those are in Sub-Saharan Africa. At least 1/3 of infants born in Sub-Saharan Africa have been exposed to maternal HIV infection and antiretroviral treatment. Majority of HIV is Read More