anti-hepatitis B core antigen (anti-HBc)

This is an antibody to the hepatitis B core antigen. The core antigen is found on virus particles but disappears early in the course of infection. This antibody is produced during and after an acute HBV infection and is usually found in chronic HBV carriers as well as those who have cleared the virus, and usually persists for life. Anti-HBc testing is either specific for the IgM antibody, which indicates acute infection, or measures total antibody, anti-HBC, which indicates past infection which could be either acute or chronic.

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