February 2025
Gaurang Telang has been an ambassador since 2022, we highlighted him as Ambassador of the Month in January 2022. He has been a great addition to the team contributing news, course content and interviews. We caught up with him 3 years later to see how his scientific career has progressed.
Please can you introduce yourself and tell us about your journey in immunology research since 2022?
I am Gaurang Telang, currently pursuing a PhD at Amity Institute of Biotechnology, Amity University Mumbai, while also working as a Laboratory Operations Manager at BioRadius Therapeutic Research Pvt. Ltd., Pune. My research focuses on T cell immunology, specifically investigating the effects of MAGE-A3 on T cell functionality and exhaustion in lung cancer.
Since 2022, my journey in immunology has been both challenging and rewarding. I have worked extensively with flow cytometry, primary cell culture, and immune cell functional assays to better understand T cell behaviour in the tumour microenvironment. Additionally, I have been involved in multiple collaborations, technical discussions with industry experts, and mentoring students in immunological research. Over the years, my focus has expanded from basic immunology to translational research, aiming to bridge the gap between fundamental discoveries and clinical applications.
We would love to hear more about your ongoing research now three years later. What projects are you currently working on and how do they impact the field?
Currently, my research is centred on three major objectives:
- MAGE-A3 and T Cell Activation: Investigating how MAGE-A3 influences early T cell activation markers and cytokine secretion.
- Memory and Exhaustion Phenotype: Studying MAGE-A3-specific T cell memory responses and its role in reversing T cell exhaustion induced by chronic stimulation.
- T Cell Cytotoxicity and Cancer Interaction: Assessing the functional impact of MAGE-A3-treated T cells on lung cancer cell lines, specifically their cytotoxic potential and tumour-killing efficacy.
These studies could provide insights into novel immunotherapeutic strategies targeting lung cancer by modulating T cell responses. If successful, they may contribute to the development of improved adoptive T cell therapies or cancer vaccines.
What inspired you to choose immunology as your focus within the field of science? Has this evolved over time?
My interest in immunology was sparked during my undergraduate studies when I first learned about the complexity and precision of the immune system. The idea that immune cells could recognize and eliminate cancerous or infected cells fascinated me. As I progressed in my career, I realized the vast potential of immunotherapy in treating cancers, autoimmune diseases, and infections.
Over time, my perspective has evolved from simply understanding immune responses to actively exploring ways to manipulate them for therapeutic benefits. Collaborating with patient-derived samples and tumour immunology models has deepened my appreciation for the challenges in the field and the need for translational approaches.
What specifically stood out about Immunopaedia that made you want to become an ambassador, and how has your experience as an ambassador affected you?
Immunopaedia stood out to me as a platform that effectively bridges knowledge gaps in immunology by making complex concepts accessible to students, researchers, and clinicians worldwide. The diversity of content—from foundational immunology to cutting-edge research—resonated with my passion for science communication.
As an ambassador, I have had the opportunity to contribute articles, conduct interviews with immunologists, and promote immunology education. This role has not only strengthened my understanding of the field but also connected me with a global network of experts and researchers. It has been a fulfilling experience to contribute to the dissemination of immunology knowledge and engage with a broader scientific community.
Based on your own experience, what one piece of advice would you give someone who wants to study or research immunology in today’s scientific landscape?
The field of immunology is rapidly evolving, and staying updated is crucial. My advice to aspiring immunologists is to cultivate a mindset of continuous learning and interdisciplinary thinking. Immunology intersects with genomics, bioinformatics, and even artificial intelligence, making it essential to explore beyond traditional boundaries.
Additionally, hands-on experience is invaluable – engaging in lab work, learning flow cytometry, and working with primary cell cultures can significantly enhance understanding. Lastly, networking with fellow researchers and mentors through conferences, workshops, and platforms like Immunopaedia can open doors to new opportunities and collaborations.
Can you share a moment of unexpected joy or surprise in your scientific career over the past three years that has stayed with you?
One of the most memorable moments in my career was when my first co-authored research paper was published. It was a significant milestone, marking the culmination of months of effort, troubleshooting experiments, and refining our hypotheses. Seeing our work recognized and available for the scientific community to read was incredibly fulfilling.
Another moment of joy was mentoring students in the lab and witnessing their growth in scientific thinking. Watching them develop their research skills, critically analyse data, and confidently present their findings has been one of the most rewarding aspects of my journey.
May we please have your most recent publications?
- Characterization and angiogenic potential of CD146 endometrial stem cells September 2024, Stem Cell Research & Therapy – http://dx.doi.org/10.1186/s13287-024-03918-7
- Comparative analyses of anti-inflammatory effects of Resveratrol, Pterostilbene and Curcumin: in-silico and in-vitro evidences May 2024, In Silico Pharmacology – (http://dx.doi.org/10.1007/s40203-024-00211-6)
- T Cell Exhaustion and Activation Markers in Pancreatic Cancer: A Systematic Review September 2023, Journal of Gastrointestinal Cancer – (http://dx.doi.org/10.1007/s12029-023-00965-w)
January 2025
Karen Sichibalo holds a master’s degree in medical parasitology from the University of Zambia and is currently undertaking a PhD in immunology at the University of Lübeck in Germany. Her passion for immunology stems from a strong interest in understanding host-pathogen interactions and leveraging this knowledge to develop host-directed therapies that would strengthen the immune system while complementing conventional treatments in fighting HIV and tuberculosis. She is particularly drawn to how the field of immunology offers endless opportunities to uncover various mechanisms underlying disease and how these insights can be used in therapeutic approaches including vaccine design.
We would love to hear more about your ongoing research. What projects are you currently working on and how do they impact the field?
My PhD research focuses on the potential benefits of high-dose vitamin D3 supplementation on innate immunity and antimycobacterial responses in adolescents living with perinatally acquired HIV-1 in Zambia. The aim is to ascertain whether vitamin D3 can be used as immunomodulatory adjuvant therapy to complement ART and reduce the incidence of microbial infections and ameliorate immune exhaustion in this cohort. We intend to ascertain this through a 96-week randomized double blinded placebo-controlled clinical trial, called VITALITY, where 400 adolescents living with HIV in Zambia received a biweekly supplementation of 20,000 IU vitamin D3 and 500 mg daily calcium carbonate (Trial ID: PACTR20200989766029). We intend to assess how vitamin D3, as a host-directed therapy, enhances neutrophil and monocyte effector functions such as phagocytic capacity and oxidative burst as well as microbial killing capacity and how it impacts chemo-/cytokine regulation in this cohort.
For resource-limited settings such as Zambia and most parts of the sub-Saharan region where HIV is a huge burden, vitamin D3 presents us with a scalable cost-effective adjuvant therapy to complement ART. Additionally, vitamin D supplementation in especially severely deficient individuals could potentially translate into reduced cases of antimicrobial resistance, in that, these individuals would be able to mount sufficient immunological responses against microbial infections. Consequently, this would ultimately reduce the use of antibiotic-dependent approaches to combat bacterial infections.
Another research project I am working on is exploring the crosstalk between gut microbiota and innate immunity in healthy adolescents and those living with HIV-1. Of note is that adolescence is a critical transitional phase in which the innate immune system undergoes maturation and becomes more robust at recognizing and killing pathogens. Significant changes in the gut microbiome composition also occur during this stage. Additionally, the innate immune system is the body’s first line of defence against pathogens and it shares a close relationship with the gut microbiota. Therefore, unravelling the crosstalk between innate immune reactivity and the gut microbiota may help us understand how gut microbiota profiles regulate the innate immune system and how this shapes disease outcomes. In this study, we hypothesize that the gut microbiota modulates innate immune responses and inflammation, potentially shaping long-term health outcomes as these adolescents transition into adulthood, with distinct differences between healthy individuals and those living with HIV.
There are many areas of science, what inspired you to choose immunology over other branches of science?
The blend of complexity that comes with immunology and its clinical impact as well as potential for transformative discoveries makes it one of the most exciting and rewarding fields to pursue. When it comes to global health, immunology is at the heart of combating pandemics and emerging infectious diseases. It plays a cardinal role in understanding the various disease mechanisms and informs the development of respective vaccines and immunotherapies. Besides, immunology is an everyday relevance because the immune system is at work every single day! Understanding immunology empowers an individual to make informed decisions about their health, from appreciating how nutrition and lifestyle impact immunity to understanding the science behind vaccines and why they are important.
What specifically stood out about Immunopaedia that made you want to be an ambassador?
Immunopaedia provides an excellent platform that promotes networking/collaborations amongst young and upcoming immunologists in Africa and across the globe. It also facilitates additional learning through the different immunology modules available on the Immunopaedia website. I appreciate the fact that these modules have been categorized into specific fields i.e. HIV/AIDS, tuberculosis, COVID etc., that particularly makes them relevant based on an individual’s field of study.
Based on your own experience, what one piece of advice would you give someone who wants to study/research immunology?
To be open-minded! Immunology is a multidisciplinary science that intersects various fields, including microbiology, genetics and bioinformatics. This integration fosters innovation and novel discoveries. It is also important to understand that negative results either from a clinical trial or in vitro experiments are still valuable. They not only explain differences in experimental conditions but most importantly help highlight differences across study populations that may ultimately warrant further study.
What has been a moment of unexpected joy or surprise in your scientific career that has stayed with you?
My greatest awe in my scientific journey is that, while many scientific disciplines play crucial roles, Immunology lies at the heart of understanding and combating diseases.
Karen Sichibalo’s recent publications:
Dzavakwa, N.V., Chisenga, M., McHugh, G., Filteau, S., Gregson, C.L., Kasonka, L., Kranzer, K., Mabuda, H.B., Mujuru, H., Redzo, N., Rowland-Jones, S., Schaible, U.E., Simms, V., Ferrand, R.A., the VITALITY team*, 2024. Vitamin D3 and calcium carbonate supplementation for adolescents with HIV to reduce musculoskeletal morbidity and immunopathology (VITALITY trial): study protocol for a randomised placebo-controlled trial. Trials 23, 78. (https://doi.org/10.1186/s13063-024-08342-z.).
Karen Sichibalo*, Katendi Changula , Chisoni Mumba , Natasha Mwila , Kennedy Chibesa, Benjamin Mubemba, King S. Nalubamba, Walter Muleya, Edgar Simulundu , Simbarashe Chitanga. (2021). Acaricide Resistance in Rhipicephalus and Amblyomma Ticks (Acari Ixodidae) in Namwala, Zambia. ( https://doi.org/10.53974/unza.jabs.5.3.668).
