In 1982, Gerhard Opelz, at the University of Heidelberg (Germany), launched the Collaborative Transplant Study (CTS), an international collaborative program involving a large number of transplant groups and tissue typing laboratories. The data collected through CTS clearly demonstrated an important effect of HLA matching on kidney graft survival. The CTS has been a great source of very important information on factors influencing long-term graft survival following organ transplantation.
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