The Cellular Selection Theory

“The process of natural selection requires the selective multiplication of a few species out of a diverse population. As a working hypothesis it is tempting to consider that one of the multiplying units in the antibody response is the cell itself. According to this hypothesis, only those cells are selected for multiplication whose synthesized product has affinity for the antigen injected”.

Talmage, D.W., Annu Rev Med 8:239-256, 1957

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